Osteoarthritis

Pathogenesis - Prevention of Post-Traumatic OA

Abstract

Abstract

The University of Iowa Specialized Center of Research (SCOR) in Osteoarthritis (OA) will support and coordinate a multidisciplinary group of experienced investigators in clinical, bioengineering, cell and molecular biology research to advance understanding of the pathogenesis of post-traumatic OA, and develop innovative approaches for preventing and treating this disease. Joint trauma dramatically increases the risk for development of OA. Yet, little work has been done on the pathogenesis and prevention of post-traumatic OA. For these reasons, a clear and urgent need exists to improve the understanding of this common and disabling disorder and our ability to prevent and treat it. The human ankle joint provides a unique opportunity for the study of post-traumatic OA because of the low risk of primary OA and the relatively high risk of post-traumatic OA. This SCOR will test the hypotheses that: 1) exceeding critical levels of acute energy absorption and chronic articular surface contact stress causes post-traumatic ankle OA, 2) the risk of OA following joint trauma increases with age as a result of decreased ability of chondrocytes to restore or maintain the articular cartilage, and 3) decreasing articular surface contact stress will decrease the risk of post-traumatic OA and provide effective treatment for ankle OA. The specific projects will include: 1) a prospective clinical study to define the relationships between acute energy absorption and chronic articular surface contact stress and the risk of post-traumatic ankle OA, 2) a prospective clinical study of the effects of decreasing articular surface contact stress in osteoarthritic ankles, 3) basic scientific and experimental investigations of the pathogenesis of post-traumatic OA, and 4) basic in vitro investigations of the effects of age and mechanically induced oxidative stress on chondrocyte senescence and the effects of anti-oxidant defenses on chondrocyte senescence. These projects will contribute significantly to the understanding of the pathogenesis of post-traumatic OA and will lay the foundation for new methods of preventing and treating this disease, as well as other forms of OA. As a result of the integrated multi-disciplinary scientific approach focused on a well-defined research theme, this SCOR will create a national resource for rapid advancements in the understanding of the pathogenesis, prevention, and treatment of post-traumatic osteoarthritis.

Personnel

Name	Organization	Role on Project
Buckwalter, Joseph A, M.S., M.D.	The University of Iowa	Principal Investigator
Brown, Thomas D., Ph.D	The University of Iowa	Co-Principal Investigator
Marsh, J. L., M.D.	The University of Iowa	Project Principal Investigator
Saltzman, Charles L., M.D.	The University of Iowa	Project Principal Investigator
McKinley, Todd O., M.D.	The University of Iowa	Project Principal Investigator
Buckwalter, Joseph A, M.S., M.D.	The University of Iowa	Project Principal Investigator
Brown, Thomas D., Ph.D.	The University of Iowa	Core Principal Investigator
Amendola, Annunziato, M.D.	The University of Iowa	Investigator
Bolinger, Lizann, Ph.D.	The University of Iowa	Investigator
El-Khoury, George Y., M.D.	The University of Iowa	Investigator
Grosland, Nicole M., Ph.D.	The University of Iowa	Investigator
Heiner, Anneliese D., Ph.D.	The University of Iowa	Investigator
Hillis, Stephen L., Ph.D.	The University of Iowa	Investigator
Martin, James A., Ph.D.	The University of Iowa	Investigator
Pedersen, Douglas R., Ph.D.	The University of Iowa	Investigator
Rudert, M. James, Ph.D.	The University of Iowa	Investigator
English, Anthony E., Ph.D.	The University of Iowa	Collaborator
Klingelhutz, Aloysius J., Ph.D.	The University of Iowa	Collaborator
Buettner, Garry R., Ph.D.	The University of Iowa	Consultant
Dircks, Herbert, Erd. Mach. Sr. Ld.	The University of Iowa	Consultant
Ashman, Robert F., M.D.	The University of Iowa	U of Iowa Advisory Committee
Butler, P. Barry, Ph.D.	The University of Iowa	U of Iowa Advisory Committee
Mark, Allyn L., M.D.	The University of Iowa	U of Iowa Advisory Committee
Peloso, Paul, M.D., M.Sc.	The University of Iowa	U of Iowa Advisory Committee
Welsh, Michael J., M.D.	The University of Iowa	U of Iowa Advisory Committee
Grodzinsky, Alan J. Ph.D.	Massachusetts Institute of Technology	External Advisory Committee
Lafeber, Floris P.J.G., Ph.D.	University of Utrecht, Netherlands	External Advisory Committee
Lewis, Jack L., Ph.D.	University of Minnesota	External Advisory Committee
Lohmander, Stefan, M.D., Ph.D.	Lund University, Sweden	External Advisory Committee
Sandell, Linda J., Ph.D.	Washington University	External Advisory Committee
Sangeorzan, Bruce, M.D.	University of Washington	External Advisory Committee
Van Roermund, Peter M., MD, PhD	University Hosp. Utrecht, Neth.	External Advisory Committee