Osteoarthritis

Pathogenesis - Prevention of Post-Traumatic OA

Contents

* Abstract

* Personnel

* Projects

* Laboratories

* Contact Information

* Related Projects

* Patient Information

* Publications

 

Abstract

The University of Iowa Specialized Center of Research (SCOR) in Osteoarthritis (OA) will support and coordinate a multidisciplinary group of experienced investigators in clinical, bioengineering, cell and molecular biology research to advance understanding of the pathogenesis of post-traumatic OA, and develop innovative approaches for preventing and treating this disease. Joint trauma dramatically increases the risk for development of OA. Yet, little work has been done on the pathogenesis and prevention of post-traumatic OA. For these reasons, a clear and urgent need exists to improve the understanding of this common and disabling disorder and our ability to prevent and treat it. The human ankle joint provides a unique opportunity for the study of post-traumatic OA because of the low risk of primary OA and the relatively high risk of post-traumatic OA. This SCOR will test the hypotheses that: 1) exceeding critical levels of acute energy absorption and chronic articular surface contact stress causes post-traumatic ankle OA, 2) the risk of OA following joint trauma increases with age as a result of decreased ability of chondrocytes to restore or maintain the articular cartilage, and 3) decreasing articular surface contact stress will decrease the risk of post-traumatic OA and provide effective treatment for ankle OA. The specific projects will include: 1) a prospective clinical study to define the relationships between acute energy absorption and chronic articular surface contact stress and the risk of post-traumatic ankle OA, 2) a prospective clinical study of the effects of decreasing articular surface contact stress in osteoarthritic ankles, 3) basic scientific and experimental investigations of the pathogenesis of post-traumatic OA, and 4) basic in vitro investigations of the effects of age and mechanically induced oxidative stress on chondrocyte senescence and the effects of anti-oxidant defenses on chondrocyte senescence. These projects will contribute significantly to the understanding of the pathogenesis of post-traumatic OA and will lay the foundation for new methods of preventing and treating this disease, as well as other forms of OA. As a result of the integrated multi-disciplinary scientific approach focused on a well-defined research theme, this SCOR will create a national resource for rapid advancements in the understanding of the pathogenesis, prevention, and treatment of post-traumatic osteoarthritis.

 

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Personnel

Name

Organization

Role on Project

Buckwalter, Joseph A, M.S., M.D.

The University of Iowa

Principal Investigator

Brown, Thomas D., Ph.D

The University of Iowa

Co-Principal Investigator

Marsh, J. L., M.D.

The University of Iowa

Project Principal Investigator

Saltzman, Charles L., M.D.

The University of Iowa

Project Principal Investigator

McKinley, Todd O., M.D.

The University of Iowa

Project Principal Investigator

Buckwalter, Joseph A, M.S., M.D.

The University of Iowa

Project Principal Investigator

Brown, Thomas D., Ph.D.

The University of Iowa

Core Principal Investigator

Amendola, Annunziato, M.D.

The University of Iowa

Investigator

Bolinger, Lizann, Ph.D.

The University of Iowa

Investigator

El-Khoury, George Y., M.D.

The University of Iowa

Investigator

Grosland, Nicole M., Ph.D.

The University of Iowa

Investigator

Heiner, Anneliese D., Ph.D.

The University of Iowa

Investigator

Hillis, Stephen L., Ph.D.

The University of Iowa

Investigator

Martin, James A., Ph.D.

The University of Iowa

Investigator

Pedersen, Douglas R., Ph.D.

The University of Iowa

Investigator

Rudert, M. James, Ph.D.

The University of Iowa

Investigator

English, Anthony E., Ph.D.

The University of Iowa

Collaborator

Klingelhutz, Aloysius J., Ph.D.

The University of Iowa

Collaborator

Buettner, Garry R., Ph.D.

The University of Iowa

Consultant

Dircks, Herbert, Erd. Mach. Sr. Ld.

The University of Iowa

Consultant

Ashman, Robert F., M.D.

The University of Iowa

U of Iowa Advisory Committee

Butler, P. Barry, Ph.D.

The University of Iowa

U of Iowa Advisory Committee

Mark, Allyn L., M.D.

The University of Iowa

U of Iowa Advisory Committee

Peloso, Paul, M.D., M.Sc.

The University of Iowa

U of Iowa Advisory Committee

Welsh, Michael J., M.D.

The University of Iowa

U of Iowa Advisory Committee

Grodzinsky, Alan J. Ph.D.

Massachusetts Institute of Technology

External Advisory Committee

Lafeber, Floris P.J.G., Ph.D.

University of Utrecht, Netherlands

External Advisory Committee

Lewis, Jack L., Ph.D.

University of Minnesota

External Advisory Committee

Lohmander, Stefan, M.D., Ph.D.

Lund University, Sweden

External Advisory Committee

Sandell, Linda J., Ph.D.

Washington University

External Advisory Committee

Sangeorzan, Bruce, M.D.

University of Washington

External Advisory Committee

Van Roermund, Peter M., MD, PhD

University Hosp. Utrecht, Neth.

External Advisory Committee

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Projects

* Main Proposal: SCOR in Post-Traumatic Osteoarthritis

* Project 1: Mechanical Determinants of Post-Traumatic Osteoarthritis

* Project 2: Effects of Distraction and Motion on Osteoarthritis

* Project 3: Pathomechanical Etiology of Post-Traumatic Osteoarthritis

* Project 4: Oxidative Stress in Post-Traumatic Osteoarthritis

* Biomechanics Core: Biomedical Engineering in Post-Traumatic Osteoarthritis

 

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Laboratories

* Biomechanics Laboratory

* Biochemistry and Cell Biology Laboratories

 

 

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Contact Information

Department Research Administrator

Lois Lembke

 

Department of Orthopaedic Surgery

The University of Iowa

1182 ML

Iowa City, Iowa 52242

E-mail address

Lois-Lembke@uiowa.edu

Office phone

(319) 335-7548

 

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Related Projects

* NIAMS -- Bioengineering Research Partnership

* Whitaker -- DDH

* CDC -- Joint Instability

* OREF McKinley: Post-Traumatic OA

* OREF-Saltzman: Total Ankle Replacement

* OREF-Marsh: Tibial Plafond Fractures

* AF - Pilon Fractures

* NIA Aging of Human Chondrocytes

 

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Patient Information

Osteoarthritis

* Virtual Hospital

* Orthopaedic Surgery at the University of Iowa

* Ankle Arthritis Center

 

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Publications

* Articles

* Abstracts

* Presentations

* Submissions

 

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Last revised: 10/14/2002 10:30 AM